Find Doctors Find Hospitals
× Find Doctors Find Hospitals Treatments sign in +91-90 7005 7005
Home » Treatment » Bone Marrow Transplant

Bone Marrow Transplant

Bone marrow transplant is a medical procedure to replace an unhealthy bone marrow which is unable to produce blood cells with a healthy one. Bone marrow is a spongy part inside some of the bones of our body like our hip & thigh bone. It contains hematopoietic stem cells which produce the three types of blood cells:

 

Red blood cells that carry oxygen to all the cells of the body

White Blood cells that keep you safe from infections 

Platelets that help in clotting of blood 

 

That is why bone marrow transplant is also known as stem cell transplant. 

 

When is a bone marrow transplant done?

Various ailments both acute as well as chronic may affect the functioning of the bone marrow. The transplant is suggested by the doctors only when there is no other way out. 

 

Some of the conditions that may require bone marrow transplant are:

 

  • Multiple Myeloma

  • Amyloidosis

  • Acute or chronic Leukemia

  • Hodgkin’s or Non-Hodgkin’s Lymphoma

  • Myelofibrosis

  • Sarcoma

  • Germ cell tumors

  • Plasma cell disorders

  • Neuroblastoma

  • Immune disorders

  • Macroglobulinemia

  • Autoimmune disorders

  • After cancer treatments like chemotherapy or radiation

 

What to do once a bone marrow transplant has been advised?

Once the bone marrow transplant is advised to you, you have to decide which type of transplant will be suitable for you. You may discuss this with your doctor who will guide you through. 

 

There are two types of bone marrow transplants:

 

Autologous

This transplant involves injecting your own previously preserved stem cells in your body. This is an option when you are about to undergo chemotherapy and you may be advised by your doctors to preserve your stem cells in case a need arises. These stem cells are stored in a stem cell bank and used if you require bone marrow transplant in the future. 

 

Allogeneic 

In allogeneic transplant, the stem cells are taken from a compatible donor which mostly is a close relative but it can be someone unknown as well. The stem cells from the donor are retrieved before the procedure and then injected into the recipient. In some cases, the mothers after giving birth to their baby, donate the stem cells from the newborn's umbilical cord for preservation that can be utilised for someone in future. This is known as a cord blood transplant.

 

Preparation for a Bone Marrow Transplant

Before finalizing you as a candidate for bone marrow transplant, you will have to go through various screening tests and procedures to determine whether you are healthy enough to undergo the transplant. These screening tests may include routine blood tests as well as scans. 

 

Before the procedure

In case of an allogeneic transplant, you will be required to find a suitable donor. The transplant team may also do a preliminary health checkup of the donor to ascertain his  compatibility with you. After this, the stem cells shall be taken from the donor’s blood or bone marrow as per the doctor’s advice and stored in a stem cell bank.

 

If you are undergoing an autologous transplant, then the blood stem cells will be collected from your body. To ensure a boost in the amount of stem cells and release these into the blood, you will be injected with a growth factor for a few days. Thereafter, blood will be taken from a vein to be directly put in a machine that aids in a process called apheresis. In this process, all the specialised cells of the blood including white blood cells, red blood cells, platelets and stem cells are separated and stored for use in the future. 

 

During the procedure

Before undergoing the actual procedure, you will be required to go through a conditioning process. In this, certain chemotherapy drugs will be administered to you to suppress your immune function. This is done to ensure that your body accepts the new cells and there is no exaggerated response to the same. Also, if you have cancer, the chemotherapy drugs will be able to destroy the malignant cells. The intensity of the conditioning drugs will depend on various factors including your disease condition, age and overall health status. These conditioning drugs may also result in certain side effects such as:

 

  • Mouth ulcers

  • Nausea

  • Vomiting

  • Infection

  • Bleeding

  • Anemia

  • Heart, liver or lung failure

 

Once the conditioning is done, the stem cells will be injected into your blood via an intravenous catheter that will be placed near your neck in your chest. This central line will remain for a few days for injecting the medications into your system. This is entirely a painless procedure which does not require anesthesia.  

 

After the procedure 

The stem cells injected into your body are meant to enter your bone marrow and start multiplying. Thereafter, if all goes well, the production of new blood cells starts. This whole process known as engraftment may take many days or even weeks.

 

The progress shall be monitored with  regular blood tests and you may require infusion of blood cells till your own bone marrow becomes functional. You should also be on the lookout for any side effects such as infection, nausea, vomiting and contact the doctor in case of any such occurrences.

 

If you do not have any other side effects or symptoms, you may be discharged from the hospital after a few days. However, you may be required to visit the hospital for regular follow ups. It is advisable for the patient & their family to arrange for a stay nearby to the hospital as it may take about an year for the body to get accustomed to the stem cells and to develop the immunity. 

 

What are the possible complications after a bone marrow transplant?

There may be a chance that there are no complications in your case after the transplant but it is essential to remain aware of the same.

 

Graft versus host disease (GVHD)

If you have undergone allogeneic transplant, then you are at risk of GVHD which is more likely to occur if you have taken the stem cells from an unrelated donor. However, it can occur otherwise as well. The symptoms of GVHD may occur within the first month or even after a longer duration of time. These may include:

 

  • Skin rashes

  • Cough and breathlessness

  • Nausea and vomiting

  • Jaundice

  • Dry eyes

  • Joint pains

  • Change in appetite, bloating or Diarrhoea

 

The other complications that might occur are:

 

  • Organ damage

  • Cancer

  • Infection

  • Bleeding

  • Eye problems such as cataract

  • Infertility

  • Liver or kidney problems

  • Breathing problems 

  • Cramps or numbness in arms or legs

 

Self-care

After discharge from the hospital, you will have to be careful of your nutrition needs and physical activity. Consulting a nutritionist will be a wise decision so that you do not have any doubts about what to eat and avoid. 

 

Apart from that:

 

  • Be careful of taking the medications on time

  • Staying physically active as much as possible

  • Staying away from any kind of infection

  • Avoiding alcohol or tobacco intake

  • Take supplements as per doctor’s advice

 

The entire transplant process can be overwhelming for some people, so if you feel that you are unable to cope with the stress or are facing anxiety issues, do not hesitate to opt for counselling session with a mental health expert. 






 

How to prepare for the procedure?

Before undergoing the procedure, you will be required to undergo certain tests and screenings so as to assess and evaluate your overall health. This is important to ensure that you are physically prepared for the procedure. An intravenous catheter (central line) will also be introduced in a large vein of your neck. This is used later on for infusing the new stem cells and medicines into the patient’s body.

How is the procedure performed?

The procedure starts with the collection of healthy stem cells

  • Autologous transplant –The procedure is usually performed on patients undergoing high dose chemotherapy. The patient is given regular injections of growth factor to enhance stem cell production and move these cells into your bloodline so that these can be easily collected. The patient is then required to undergo a procedure known as apheresis in which the blood is drawn out from the patient’s body and circulated to separate the stem cells from the other components. These stem cells are preserved to be returned to the patient’s body post-chemotherapy.
  • Allogeneic transplant –In this case, there is a need for b a suitable donor who is willing to donate his/her stem cells. These can be collected either from the donor’s blood or bone marrow. Cord blood transplant may also be performed in which the stem cells are taken from the umbilical cord of babies right after birth and then stored to be used later. The baby’s mother can choose to donate the umbilical cords right after their delivery.

This is then followed by the conditioning process

The patient is subjected to chemo or radiation therapy

  • To kill all the malignant cell
  • To suppress the patient’s immune system
  • Prepare the bone marrow for the transplant of new stem cells.

The intensity of the conditioning therapy varies from one patient to another depending upon their health history and age.

The final step is the transplant

The collected stem cells are infused into the patient’s body via the intravenous catheter or central line. These stem cells travel to the bone marrow via the bloodline and gradually multiply to facilitate the production of healthy blood cells. This process is known as engraftment. It may take a few weeks for your blood count to return back to normal.

What follows after Bone Marrow Transplant?

After the bone marrow transplant, the patient will be kept under keen medical supervision and may be discharged within a few days or even a week depending upon how well he/she is responding to the treatment. In certain case, the patient might require periodic transfusion of red blood cells and platelets until the bone marrow starts producing these on its own.

Also, it is pertinent to understand that the immunity of the recipient is significantly compromised for the first few months following the transplant, hence it is important to take extra precautions.

The patient is required to make certain healthy lifestyle and dietary changes and restrict alcohol intake.

What are the benefits of Bone Marrow Transplant?

The goal of the bone marrow transplant depends upon the condition of the individual but there are certain benefits that are common to all. These include:

  • Better quality of life
  • Longer life span
  • Relief from symptoms

Are there any risks involved?

Some of the major risks associated with bone marrow transplant include:

  • Low cell count
  • Graft failure
  • Graft versus host disease
  • Infection
  • Late effects

Our Doctors

1621341846_dr-chandragouda-(1).jpg

Dr. Chandragouda Dodagoudar

Director - Medical Oncology

Dr. Chandragouda Dodagoudar has been practicing oncology medicine with cumulative clinical experience of more than 14 years and has considerable expertise in treating..
1621341846_dr-chandragouda-(1).jpg

, Delhi

1000 Consultation fee

NEXT AVAILABLE AT

1:00 PM, Today

1:00 PM, Today

Overall rating

0 0 reviews

Hospital Plot, Road Number 201, Sector-3, Dwarka, New Delhi-110075

1000

Monday to Saturday

Waiting Time : 4-5 Min

images     Not Available    

images Book An Appointment

Select a time slot
images

Dr. Chandragouda Dodagoudar

Director - Medical Oncology,

Hospital Plot, Road Number 201, Sector-3, Dwarka, New Delhi-110075

Pick Time (4 Slots available)

Patient Info

  • Get Flat 20% Off on Online Payments*

1584339397_dharma-132.jpg

Dr. Dharma Choudhary

Senior Director & HOD Bone Marrow Transplant

Dr. Dharma Choudhary Presently working as a Senior Director & HOD in Bone Marrow Transplant Department at BLK Super Speciality Hospital, New Delhi ..
1584339397_dharma-132.jpg

, Delhi

1000 Consultation fee

NEXT AVAILABLE AT

1:00 PM, Today

1:00 PM, Today

Overall rating

0 0 reviews

BLK Super Speciality Hospital Pusa Road, New Delhi-110005

1000

Mon-Sat

Waiting Time : 4-5 Min

images     Not Available    

images Book An Appointment

Select a time slot
images

Dr. Dharma Choudhary

Senior Director & HOD Bone Marrow Transplant,

BLK Super Speciality Hospital Pusa Road, New Delhi-110005

Pick Time (4 Slots available)

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

1621345115_IMG-20190503-WA0012.jpg

Dr. Renuka Gupta

Consultant - Gynecologic oncology

Dr Renuka Gupta is a Consultant Gynaecologist and Oncologist at Action Cancer Hospital, with thirteen years of experience in Gynaecology and Gynae-Oncology. ..
1621345115_IMG-20190503-WA0012.jpg

, Delhi

1000 Consultation fee

NEXT AVAILABLE AT

1:00 PM, Today

1:00 PM, Today

Overall rating

0 0 reviews

FC 34, A-4 Paschim Vihar East, Landmark : Opposite Dda Sports Complex Paschim Vihar, Delhi - 110063

1000

Waiting Time : 4-5 Min

images     Not Available    

images Book An Appointment

Select a time slot
images

Dr. Renuka Gupta

Consultant - Gynecologic oncology,

FC 34, A-4 Paschim Vihar East, Landmark : Opposite Dda Sports Complex Paschim Vihar, Delhi - 110063

Pick Time (4 Slots available)

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

1621343078_dr_sachin_suresh_jadhav.jpg

Dr. Sachin Jadhav

GROUP HEAD Haematology & BMT department

Dr. Sachin Jadhav is an experienced Haematologist and Bone Marrow Transplant (BMT) Physician with over 17 years of rich experience in treating blood diseases and stem..
1621343078_dr_sachin_suresh_jadhav.jpg

, Bangalore

1000 Consultation fee

NEXT AVAILABLE AT

1:00 PM, Today

1:00 PM, Today

Overall rating

0 0 reviews

Bangalore

1000

Waiting Time : 4-5 Min

images     Not Available    

images Book An Appointment

Select a time slot
images

Dr. Sachin Jadhav

GROUP HEAD Haematology & BMT department,

Bangalore

Pick Time (4 Slots available)

Patient Info

  • Get Flat 20% Off on Online Payments*

1591453980_male-132-216.jpg

Dr. Sajjan Rajpurohit

Principal Consultant - Medical Oncology & Centre Head
Max Super Speciality Hospital, Vaishali

Dr.Sajjan Rajpurohit practices as a Consultant-Medical Oncology & Centre Head at Max Super Speciality Hospital, Vaishali ..
1591453980_male-132-216.jpg

Max Super Speciality Hospital, Vaishali, Ghaziabad

1000 Consultation fee

NEXT AVAILABLE AT

1:00 PM, Today

1:00 PM, Today

Overall rating

0 0 reviews

W-3 Sector-1, Vaishali, Pincode 201012 Ghaziabad, NCR India

1000

Waiting Time : 4-5 Min

images     Not Available    

images Book An Appointment

Select a time slot
images

Dr. Sajjan Rajpurohit

Principal Consultant - Medical Oncology & Centre Head,

W-3 Sector-1, Vaishali, Pincode 201012 Ghaziabad, NCR India

Pick Time (4 Slots available)

Patient Info

  • Get Flat 20% Off on Online Payments*

1591597784_New-Picture---Dr.-Vikas-Goswami_0.jpg

Dr. Vikas Goswami

Senior Consultant - Cancer Care/ Oncology
Max Super Speciality Hospital, Vaishali

Dr.Vikas Goswami practices as a Senior Consultant-Oncology & Hematology at Max Super Speciality Hospital, Vaishali &Patparganj ..
1591597784_New-Picture---Dr.-Vikas-Goswami_0.jpg

Max Super Speciality Hospital, Vaishali, Ghaziabad

1000 Consultation fee

NEXT AVAILABLE AT

1:00 PM, Today

1:00 PM, Today

Overall rating

0 0 reviews

W-3 Sector-1, Vaishali, Ghaziabad, Uttar Pradesh 201012

1000

Waiting Time : 4-5 Min

images     Not Available    

images Book An Appointment

Select a time slot
images

Dr. Vikas Goswami

Senior Consultant - Cancer Care/ Oncology,

W-3 Sector-1, Vaishali, Ghaziabad, Uttar Pradesh 201012

Pick Time (4 Slots available)

Patient Info

  • Get Flat 20% Off on Online Payments*

1597998245_Dr.-Ranga-Rao-Webiste-image.jpg

Dr. (COL.) R. RANGA RAO

Consultant - Cardiology
Paras Hospitals, Gurugram

He has 30 Years of experience

 His areas of specialty are Cancer of Lung, Pleura, Breast, Ovarian, Cervical, Esophagus, Stomach, Small Intestine, Colon, Rectum, Liver, Gall Bladder, ..
1597998245_Dr.-Ranga-Rao-Webiste-image.jpg

Paras Hospitals, Gurugram, Gurugram

1000 Consultation fee

NEXT AVAILABLE AT

1:00 PM, Today

1:00 PM, Today

Overall rating

0 0 reviews

C-1 Sushant Lok- 1 Sector-43 Phase- I Gurgaon, Haryana 122002 (India)

1000

Mon-Sat

Waiting Time : 4-5 Min

images     Not Available    

images Book An Appointment

Select a time slot
images

Dr. (COL.) R. RANGA RAO

Consultant - Cardiology,

He has 30 Years of experience

C-1 Sushant Lok- 1 Sector-43 Phase- I Gurgaon, Haryana 122002 (India)

Pick Time (4 Slots available)

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info

  • Get Flat 20% Off on Online Payments*

Patient Info